Most TMS providers report a success rate between 70% and 80%, indicating that a significant number of individuals experience substantial relief after undergoing treatment. In contrast, commonly prescribed medications like Selective Serotonin Reuptake Inhibitors (SSRIs) have a success rate of only 27.5%, according to the NIMH-funded STAR*D study. For those with treatment-resistant depression, the success rate for subsequent medications diminishes significantly, dropping below 7% after trying four different medications. It typically takes 1-2 months to determine the effectiveness of an antidepressant, meaning that individuals may spend 4-8 months testing different medications with minimal chances of achieving remission. Moreover, increased medication usage heightens the risk of experiencing negative side effects such as sexual dysfunction, gastrointestinal discomfort, nausea, increased appetite and weight gain, insomnia, agitation, irritability, and headaches.